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Including too many cards like this in your deck makes you vulnerable to mass removal effects but this is easy enough to compensate for

Want to see how it works in practice

Delete is also a solid way to deal with a ton of creatures and make sure Missy sticks around since you can control how much damage is dealt to all creatures

Theres a huge chance theyre dead shortly after this comes down if youre remotely aggressive

Also, as you might expect, proliferating your opponents' poison counters is a strong strategy for winning games, and cards like Inexorable Tide or Contagion Engine are effective ways to achieve this